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KMID : 0378019920350040103
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New Medical Journal
1992 Volume.35 No. 4 p.103 ~ p.107
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Comparative Study of the Efficacy and Tolerance of Roxythromycin and Cefaclor in the Treatment of Respiratory Tract Infections
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Abstract
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Roxythromycin is a new semisynthetic macrolide antibiotic which has a broad antibacterial activity similar to Erythromycin, but has acid stability and longer half-life. To evaluate the clinical efficacy and safety of Roxythromycin in respiratory tract infections we carried out the comparative study of Roxythromycin and Cefaclor in randomized 60 outpatients.
The results were as follows :
1. Among 60 patients, 55 patients were evaluable. The clinical efficacy of Roxythromycin. group (29 patients) and Cefaclor group (26 patients) were 76.4% and 69.2% respectively (p> 0.05).
2. Among 26 bacterial strains cultured from sputums of-respiratory tract infections, 57.7% showed sensitivity to Roxythromycin,, and 50.0% showed sensitivity to Cefaclor (p >0.05).
3. Only mild side effects were observed in 10.3% of Roxythromycin group and 11.5% of Cefaclor group.
In conclusion, Roxythromycin was considered to be useful and safe against respiratory tract infections and was comparable to Cefaclor.
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KEYWORD
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